Fibrin-Coated Implants
Many artificial implants in soft and hard tissues are not biocompatible and may be rejected or induce foreign body inflammatory responses and bind poorly to cells. Therefore, there is a need to modify the surface area of the implants and render them more biocompatible by improving their integration in the tissues of the implanted site. We propose to enhance cell binding to the surface of the implants by a human-based cell binding protein. Examples for such a need are a variety of implants to support recovery of bone defects and stabilize fractures.
Fibrin-based matrices could be a preferred material for coating implants due to the coagulation process which allows fibrinogen transformation to fibrin and its adhesive activity with cells. Some methods have been proposed to use such coatings but the stability of the fibrin gel coat on the surface is not very high and therefore other combination of fibrin with other materials were proposed for these types of applications. We suggest a technology that can coat metallic and other surfaces with non-soluble film layers of fibrin for enhancing the cell binding to such matrices.
