The proposed product is a portable easy to use iontophoretic device that ejects a high content of anionic or cationic molecules (i.e. a drug) from a soft gel upon application of a low current for less than 120 seconds. The preferred device is a pen size, battery operated probe with a variable current. At the edge of the device is a conical or cylindrical hole for the insertion of the drug loaded hydrogel disc.
Ultra-microsurgery for Drusin Removal in AMD and Laser-Mediated Gene Transduction
There are many clinical conditions that require ultramicrosurgery, ultramicroporation and ultramicroalteration at specified depths without any collateral effects on the overlying or underlying tissue. An excellent example of this is the problem of Age Related Macular Degeneration (AMD). Our invention is the result of very promising preliminary results in the application of ultrafast lasers to the problem. These near-infrared lasers can be focused to a point below a surface and can be made to affect only the point of focus and not the overlying or underlying material through which the laser beam is
transmitted. It is also expected that a variety of other clinical procedures will benefit from the characteristics of the instrument that we have developed. These include laser-mediated gene transduction that could also offer new directions in ophthalmology.
